Hyaluronic acid is an essential component of our soft and hard tissues. As such it is found in all tooth-supporting structures, which demonstrates its role in periodontal and alveolar bone regeneration. Thanks to its water retaining and gel forming activities it has also become the focus of tissue engineering in cosmetics and many biomedical fields.
Hyaluronic acid is widely distributed throughout the human body as one major component of the extracellular matrix of many organs and tissues such as skin, muscles, tendon, gingiva and alveolar bone. Hyaluronic acid has a multitude of structural and cell regulatory functions including stimulation of angiogenesis, modulation of the immune response and regulation of intercellular communication¹.
Usability and grafting efficacy are emerging key aspects when it comes to the requirements for the ‘ideal’ bone substitute material. Handling characteristics of bone regeneration materials can be significantly improved by organic additives, with hyaluronic acid being of particular interest, because of its water-binding activities. Moreover, the performance of bone substitutes can benefit from its well described biological functions².
Data from Rakašević D et al., J Funct Biomater. 2023 Mar 8;14(3):149.³
“Hyaluronic acid has been shown to enhance the proliferative, migratory and wound healing properties of cell types involved in soft tissue wound healing thus pointing to its potential indication in oral reconstructive procedures.”
Prof. Dr. Anton Sculean, University of Bern, Switzerland
Prof. Sofia Aroca, Prof. Serhat Aslan and Dr. Miguel Stanley about cerabone® +HyA
Three experts in their field provide insight into how the application comfort of cerabone® +HyA improves their daily practice and facilitates the treatment of complex bone defects.
Featuring 14 detailed clinical cases and histological results this casebook provides insights into solving both everyday and advanced clinical challenges.
cerabone® +HyA combines the established bovine bone grafting material cerabone® with the well-known properties of hyaluronic acid. Thanks to the pronounced liquid binding capacities of hyaluronate, cerabone® +HyA forms a sticky bone material upon hydration that provides unique application comfort by allowing both easy uptake and delivery to the site of application.
maxgraft® +HyA extends the well-established maxgraft® portfolio by combining allogenic granules with hyaluronate. Due to the extraordinary liquid-binding properties of hyaluronate, maxgraft® +HyA allows for seamless preparation of sticky bone upon hydration. The combination of maxgraft®’s high biological regenerative potential and complete remodeling with the unique benefits of hyaluronate enhances clinical outcomes and supports soft tissue healing.
